WISB researchers are developing novel SB tools for engineering biosynthetic pathways to generate structurally complex bioactives in microorganisms such as Streptomyces sp. and Saccharomyces cerevisiae. Rate control engineering, combined with high-resolution systems analysis, enables us to create highly efficient synthetic pathways.
Fungal natural product discovery and biosynthesis
Discovery, biosynthesis, mechanism of action and pathway engineering of bioactive microbial natural products.G.L.Challis@warwick.ac.uk Website
Characterisation of microbial transcriptional regulators that control antibiotic biosynthesis and/or antibiotic resistance in bacteria.C.Corre@warwick.ac.uk Website
Mapping protein-protein interactions in modular polyketide synthases using structural mass email@example.com