Quantitative analysis and preparative separations of components in a chemical mixture.
The identification and structural elucidation of novel and known natural products and biosynthetic intermediates in microbial culture extracts.
Protein mass spectrometry to characterise biosynthetic enzymes and intermediates that are covalently-attached to them.
Analysis of metabolic products of natural and engineered biosynthetic pathways; characterisation of biosynthetic intermediates covalently-attached to polyketide synthase and nonribosomal peptide synthetase multi-enzymes (PI Challis)
Quantitative analysis of cations, anions, organic acids, amino acids and carbohydrates in a mixture.
Chromatographic separation of major metabolites released by microbes in defined culture media (PI Soyer)